The Astros led 1-0 going into the ninth and Houston closer Ryan Pressly struck out the first two batters. Miguel Cabrera, Zach McKinstry and Javier Baez then singled, and pinch-runner Carson Kelly scored from second on Báez’s liner into center.
Meadows, playing his fourth career game, then homered to right field.
“I saw a hanging slider and I was able to take advantage of it,” Meadows said. “This doesn’t feel real.”
Alex Lange (6-3) worked the ninth for the win. It was the fifth blown save for Pressly (3-4) in 33 opportunities.
Houston wasted a stellar start by left-hander Framber Valdez, who struck out six and walked five in seven hitless innings. Valdez, who threw a no-hitter against Cleveland on Aug. 1, matched a career high with 114 pitches.
“We couldn’t get anything in the air against him, and it seemed like everything we hit on the ground was right at an infielder,” Tigers manager A.J. Hinch said. “But our at-bats were the reason we got him out of the game in 114 pitches.
“We knew once we got to their all-righty bullpen, we could throw our lefties at them.”
Valdez, 29, became the seventh pitcher with two hitless starts of at least seven innings in a season. Max Scherzer was the last major leaguer to accomplish the feat in 2015 with the Washington Nationals.
Houston took the lead in the third. Jose Abreu reached on Short’s throwing error and Rogers was called for catcher’s interference on Jeremy Pena. After Martin Maldonado‘s sacrifice bunt moved the runners to second and third, Jose Altuve hit a high chopper for an RBI single.
Altuve’s infield single was Houston’s only hit off Matt Manning, who pitched 6⅓ innings before leaving with a back strain.
“He slipped and something in his back grabbed at him,” Hinch said. “He was brilliant, but we weren’t taking any chances.
“He’s in the middle of the celebration, so that’s a good sign.”
The Astros nearly scored again in the fourth, but Meadows made a jumping catch at the center-field wall to take extra bases away from Yordan Alvarez.
“Before tonight, Parker was best known for playing defense,” Hinch said with a smile. “We’re so happy with him in center field that we moved Riley Greene to make room for him. That says a lot.”